---
title: "CRISPR-Cas9 Gene Editing: How It Works | Model Diplomat"
description: "CRISPR-Cas9 is a precise gene-editing technology that allows targeted DNA modification, crucial for researchers and policy discussions in India and the US."
url: "https://modeldiplomat.com/learn/glossary/crispr-cas9"
---

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Model Diplomat Research Team · Last reviewed June 22, 2026

TL;DR

- CRISPR-Cas9 is a genome-editing technology that uses a guide RNA and the Cas9 enzyme to cut DNA at a targeted sequence, enabling precise gene modification.
- What is the difference between CRISPR-Cas9 and traditional GMO technology?
- Why is germline gene editing more controversial than somatic editing?
- How does India regulate CRISPR gene editing?
- How does CRISPR-Cas9 differ from TALENs and zinc-finger nucleases?

[Civil Service & Diplomatic Exams](https://modeldiplomat.com/learn/civil-services/glossary)Updated June 22, 2026

CRISPR-Cas9 is a genome-editing technology that uses a guide RNA and the Cas9 enzyme to cut DNA at a targeted sequence, enabling precise gene modification.

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In December 2023, the US FDA approved Casgevy, the first CRISPR-Cas9-based therapy, to treat sickle cell disease by editing patients' own blood stem cells.

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