---
title: "Base Editing: Precision Gene Editing Explained"
description: "Base editing is a precise genome-editing technique that alters DNA bases without double-strand breaks, crucial for advancements in genetics and medicine."
url: "https://modeldiplomat.com/learn/glossary/base-editing"
---

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Model Diplomat Research Team · Last reviewed June 22, 2026

TL;DR

- Base editing is a precision genome-editing technique that chemically converts one DNA base into another at a targeted site without cutting both strands of the double helix.
- How does base editing differ from conventional CRISPR-Cas9 editing?
- What kinds of mutations can base editing correct?
- Is base editing regulated as a genetically modified organism in agriculture?
- What are the main technical risks of base editing?

[Civil Service & Diplomatic Exams](https://modeldiplomat.com/learn/civil-services/glossary)Updated June 22, 2026

Base editing is a precision genome-editing technique that chemically converts one DNA base into another at a targeted site without cutting both strands of the double helix.

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In 2022, clinicians at Great Ormond Street Hospital, London, used base-edited donor T-cells to treat Alyssa, a teenager with relapsed T-cell leukaemia, in the first reported therapeutic application of base editing in a human.

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